Cell Lines and Cell Cultures
ATCC Primary CD56 Natural Killer Cells; Normal; Human
Primary CD56+ NK Cells exhibit lymphoid morphology and were isolated from the peripheral blood of a donor. This cell has applications in compound screening and immune function assays.
ATCC Streptococcus mutans
Streptococcus mutans strain NCTC 10449 [IFO 13955] is a whole-genome sequenced bacterial type strain isolated from carious dentine. This product has applications in media testing.
ATCC Staphylococcus capitis; subsp. capitis; Strain PRA 360 677
Staphylococcus capitis subsp. capitis strain PRA 360 677 is a whole-genome sequenced strain that can be used as a quality control strain for API products.
ATCC GH3; Pituitary Tumor; Rat (Rattus norvegicus)
GH3 is an epithelial-like cell that was isolated in 1965 from the pituitary gland of a female rat with a tumor. This cell line was deposited by AH Tashjian.
ATCC Synthetic Hepatitis; A DNA
Quantitative synthetic Hepatitis A virus DNA can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine viral load. This preparation includes genomic segments from the 5’ untranslated region, viral capsid proteins (VP1- 4), self-cleaving peptide 2A, proteinase 3C, and 3D RNA polymerase.
Eurofins Discoverx ChemiScreen SST2 Somatostatin Receptor Stable Cell Line, 2 vials. (HTS028C)
The ChemiScreen SST2 Somatostatin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin) based activation of SSTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Biochain Institute Inc Frozen Tissue Section - Human Diabetic Diseased Tissue: Kidney, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
ATCC Quantitative Genomic; DNA from; Mycoplasma hominis; Strain: PG21
Quantitative genomic DNA from Mycoplasma hominis strain PG21 (ATCC 23114). This whole-genome sequenced product can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows the generation of a standard curve for quantitative PCR (qPCR) to determine bacterial load.
Eurofins Discoverx PathHunter CXCR6 Total Internalization U2OS Cell Line, 2 vials. (93-0886C3)
The PathHunter CXCR6 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CXCR6 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged CXCR6 and a ProLink-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CXCR6 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Charles River Labs Cell Solutions PB CD8 CELLS- NEG SEL CRYO 10M
For Research Use Only. Human Normal Peripheral Blood CD8+ Cytotoxic T Cells - Cryopreserved, 10 million cells/vial. Isolated using NEGATIVE immunomagnetic cell separation procedures.
ATCC Vibrio alginolyticus
Vibrio alginolyticus strain XII-53 is a whole-genome sequenced bacterial type strain that was isolated in Japan from spoiled horse mackerel that resulted in food poisoning. It has applications in bioinformatics.
Genscript Corporation CHO-K1/Cyno CD47 Stable Cell L
This gene encodes a membrane protein which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin and it may play a role in membrane transport and signal transduction This gene has broad tissue distribution and is reduced in expression on Rh erythrocytes Alternatively spliced transcript variants have been found for this gene
ACROBiosystems HEK293/Human GPR75 Stable Cell Line
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Genscript Corporation CHO-K1/KIR Stable Cell Line
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and are subsets of T cells The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM) while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals The ligands for several KIR proteins are subsets of HLA class I molecules thus KIR proteins are thought to play an important role in regulation of the immune response
Eurofins Discoverx PathHunter U2OS ACVR1C/ACVR2B Dimerization Cell Line, 2 vials. (93-1047C3)
The PathHunter ACVR1C/ACVR2B Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. activin B) induced dimerization of ACVR1C/ACVR2B receptors. This product uses EFC technology. The cell line included overexpresses ACVR2B target protein fused to PK alongside ACVR1C target protein fused to EA. Upon ligand-induced dimerization of ACVR1C/ACVR2B, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.